Some recent items related to health issues.
Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer's disease. Patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU. These findings demonstrate the existence of anti-inflammatory exercise factors that are transferrable, target the cerebrovasculature and benefit the brain, and are present in humans who engage in exercise.
It's important to note that observed associations like this - even on a huge scale - are not the same as proof of a causative effect. For example, it's possible that the people in the cohort who took sildenafil might have something else to thank for their improved chances of not developing Alzheimer's.
Particularly with obesity and diabetes, those risk factors have been getting worse instead of better. We haven't, apparently, come up with strategies to turn that around.
On top of that, the other main reason for seeing a drop in life expectancy - other than obesity and COVID - is the opioid crisis.
Eight years ago, a team of researchers launched a project to carefully repeat early but influential lab experiments in cancer research.
They recreated 50 experiments, the type of preliminary research with mice and test tubes that sets the stage for new cancer drugs. The results reported Tuesday: About half the scientific claims didn't hold up.
Watch with wonder as the Social Distance Zapper extends from one foot folded to five feet extended! Keep the anti-maskers at bay with just three LR44 batteries to power this 4.5 v zapper.